Ascorbate Effect of Lithium on Protein and Lipid Metabolism in Pigs

The aim of the study was to investigate the effect of a new anti-stress drug on protein and lipid metabolism in thecultivation and fattening of pigs. The experiment was carried out on 5 groups of pigs of Irish Landrace breed (4experimental and 1 control) with 10 heads in each in the period from 60 to 210 days of age. Animals of 1, 2, 3and 4 experimental groups daily during the entire period of rearing and fattening received lithium ascorbate inthe form of powder at a dose of 10, 5, 2 and 0.5 mg/kg of live weight, respectively. Weighing was carried outbefore the introduction of the drug, for the 4th month and before slaughter. Before setting the animals in theexperiment and on the 180th day of the experiment, blood samples were taken. Triacylglycerols, total protein andglobulins, and fractions of lipoproteins were determined in blood plasma. Acting on protein and lipid metabolism,lithium ascorbate activates the functions associated with the participation of α-, β - globulins in the transport oflipids, as well as in the performance of γ-globulins protective functions. Lithium ascorbate has a positive effecton lipid-cholesterol metabolism and, as a result, contributes to the increase in live weight and quality of meat.With the introduction of feed lithium ascorbate from the 60th day prior to slaughter at a dosage of 10, 5 and 2mg/kg of body weight, lithium ascorbate exhibits a pronounced adaptogenic and stress-protection properties,prevents the accumulation of lipoproteins of low and very low density and activates the production of high-densitylipoproteins. And in the control animals, it is is observed in the reverse reaction. The use of lithium ascorbateaffects protein synthesis. Given that γ-and β-globulins serve as raw materials for the production ofimmunoglobulins, it can be noted that the animals treated with lithium ascorbate had the best opportunities forhumoral specific protection for 180 days of experience, which contributes to the increase of nonspecific immunityand resistance. The revealed effects of lithium ascorbate indicate the prospects for the development of neweffective ways to increase stress resistance, nonspecific resistance and productivity of animals using drugs basedon organic lithium salts.

Features and clinical significance of nutritional metabolism in patients with primary liver cancer / 临床肝胆病杂志

Nutritional metabolism is closely associated with the treatment of tumors and is an important research field in China and foreign countries. On the one hand, the use of nutrient metabolism pathway molecules as therapeutic targets has become a new direction in the field of biomedical research; on the other hand, poor nutritional status in patients with tumors will lead to the fact that the patients cannot be treated or have severe adverse reactions or poor prognosis, and thus it has always been a hot research topic. The liver is a metabolic organ, and the metabolism of liver tumors is different from that of tumors in other parts. Therefore, the research on nutritional metabolism in patients with liver cancer is of particular importance. This article elaborates on the changes in the metabolism of glucose, lipids, proteins, and amino acids and related molecular mechanisms in patients with primary liver cancer, in order to provide thoughts for selecting nutrient metabolism pathways in patients with liver cancer, identifying specific markers for liver cancer, and solving the issue of nutritional support during treatment and provide a reference for the research on nutritional metabolism of liver cancer.

Research progress in protein-energy metabolism and intestinal mucosa immunization in kidney diseases / 中国实用内科杂志

Immunometabolism, focusing on the changes in intracellular metabolic pathways in immune cells that alter their function, is one of the most important research fields in recent years. Researches on the metabolism of carbohydrates, lipids,and proteins of immune cells shed important light on a better understanding of the physiological and pathological mechanisms of several diseases. For example, innate and adaptive immunity have been recently confirmed to be involved in obesity, further increasing risk of type 2 diabetes, cardiovascular disease, cancer and neurodegenerative disease. Interactions between metabolic aberrations and chronic kidney diseases always lead to a vicious spiral in disease etiology and progression. Up to date, emerging evidence has also indicated a therapeutic role of immune-metabolism. In this perspective,we aim to discuss some of these novel findings, with a special focus on how protein metabolism shaping immune system and gut microbiome in kidney disease. We hope the readers find our account understandable, interesting and thought-provoking for their own research.

Clinical evaluation of protein-amino acid metabolic disorders / 中国实用内科杂志

Proteins are macro-molecules crucial for cell life, which are made up of amino acids(AAs). The biochemical consequence of hyper-catabolism is protein disarrangement, clinically evident with signs such as sarcopenia, hypalbuminemia,anaemia, infection, and altered fluid compartmentation, etc. Therefore, identification and treatment of proteins' metabolic impairment with appropriate measurements and therapy is a clinical strategy that can improve the prognosis of patients with acute/chronic hypercatabolic inflammatory disease. Here, we describe the role metabolism of protein and AAs in hypercatabolic syndrome, illustrating the clinical impact of protein disarrangement and also illustrate simple, cheap, repeatable, and worldwide available measurements to identify these conditions in order to provide scientific evidence for HPD nutritional treatment.

Regulation and mechanism of glucocorticoids on skeletal muscle metabolism / 中国药理学通报

Glucocorticoids ( GCs) have important regulatory effects on skeletal muscle metabolism. GCs can inhibit skeletal muscle glucose uptake and glycogen synthesis, and improve blood glucose levels by inhibiting Pik3rl expression, inhibiting insulin signaling pathway, or promoting pyruvate dehydrogenase kinase 4 expression; GCs can inhibit skeletal muscle lipid metabolism , causing the accumulation of lipid metabolism intermediates diacylglycerol and ceramides, and inducing skeletal muscle insulin resistance; GCs can induce MuRFl and MAFbx expression by promoting FoxO expression, activating the ubiquitin-proteasome system and autophagy lysosome system, and activating oxidative stress system, or promote the protein decomposi-tion of skeletal muscle by up-regulating C/EBPp expression; GCs can also inhibit the mTOR pathway by promoting myostatin and Pik3rl expression and inhibit skeletal muscle protein synthesis by up-regulating KLF-15 expression. This article explores the effects of GCs on skeletal muscle metabolism and its molecular mechanisms by tracking the latest developments at home and a-broad, which will provide reference for the clinical application of GCs.

Descripción de los hallazgos en el perfil lipídico y proteico de pacientes dependientes a cocaína, en abstinencia reciente / Serum lipid levels in a group of cocaine dependent subjects in recent abstinence

Background: Chronic cocaine users develop multiple potentially lethal ischemic vascular complications associated with accelerated atherosclerosis. Aim: To assess biochemical and lipid profiles among cocaine dependent subjects in recent abstinence. Material and Methods: A blood sample to measure blood count, biochemical and lipid profiles was obtained from 78 patients aged 19 to 53 years (78% males) who complied with DSM-IV criteria for cocaine dependency. Laboratory results were compared with a group of normal subjects. Results: All cases had positive urinary cocaine, with a mean consumption lapse of 7.6 years. The frequency of smoking was higher in cases. Dependent males had higher body mass index than controls. Compared to controls, dependent females had significantly higher triglyceride (TG) levels and lower HDL cholesterol. Therefore the relation total/HDL cholesterol was higher (p = 0.0365). Dependent males had higher TG levels than their normal counterparts. Dependent subjects consuming cocaine base-paste had higher TG levels. Total proteins, albumin, urea and blood urea nitrogen were lower in dependent subjects. Among males, serum creatinine was lower and blood urea was positively correlated with the daily amount of cocaine use (p = 0.03). After a month of strict abstinence, lipid profile was repeated in 27 patients and remained unchanged. Conclusions: Chronic cocaine use was associated with higher TG in both genders and lower HDL cholesterol in women when compared with a group of healthy counterparts.

Expression of Rac1 in normal and gentamicin-induced ototoxic damaged cochlea of guinea pigs / 中国医师杂志

Objective To investigate the expression of Rac 1 in the guinea pig cochlea of gentamicin-induced ototoxic damage and prevention with antioxidant sodium salicylate , and to explore the roles of Rac 1 in the ototoxic mechanism of aminoglycoside antibi-otics.Methods Thirty healthy male guinea pigs were involved in this study .All the guinea pigs were randomly divided into 3 groups and received intraperitoneal injections according to their arranged group .Group I (control) was treated with normal saline for 7 days. Group II [Gentamicin (GM)] was treated with gentamicin alone for 7 days.Group III [GM+sodium salicylate(SA)] was treated with gentamicin in combination with sodium salicylate for 7 days.Paraffin-embedded cochlear section with immunohistochemical stai-ning was used for evaluation of Rac 1 expression in the cochlea .The protein was extracted from the cochlea tissues , and Rac1 protein levels in the cochlea were detected by Western blot assay .Results Immunohistochemistry showed a slightly positive reaction for Rac 1 staining found in the cochlea of the control group was mainly shown in the cytoplasm and cytomembrane of ganglion and organ of Corti ;a highly positive expression was shown in GM group;and the extent of Rac 1 expression of GM+SA group was between the control and GM groups.Image analysis showed that the differences in Rac1 expression between each two groups were statistically significant ( P <0.05).Western blot assay showed that expression of Rac 1 protein was highest in GM group and decreased in GM +SA group, while the intensity of Rac1 protein expression in GM +SA group was between the control and GM group .Statistics analysis showed that the expression between each two groups had significant difference ( P <0.05 ) .Conclusions A slightly positive reaction for Rac 1 stai-ning was found in the cochlea of guinea pigs , and mainly observed in the cytoplasm and cytomembrane of spiral ganglion and organ of Corti.With the administration of gentamicin , Rac1 protein expression was upregulated in the cochlea .Simultaneous administration of antioxidant sodium salicylate could significantly decrease the expression of Rac 1 protein.These results indicated that Rac1 might play an important role in the processes of gentamicin-induced oxidative damage of cochlea .

Effects of depression on C-reactive protein and low-density lipoprotein levels in patients with coronary artery disease / 中国医师杂志

Objective To investigate effects of depression on C-reactive protein ( CRP) and low density lipoprotein ( LDL) levels in patients with coronary artery disease .Methods Eighty coronary heart disease patients with and without depression and 20 coronary heart disease-free cases were selected , CRP and LDL levels were measured and compared among three groups .The correlation of depression scores with CRP and LDL were analyzed .Results Depression self rating scale ( SDS) , and Hamilton Depression Scale ( HAMD) scores of patients with coronary heart disease ( CHD)+depression were 46.22 ±3.90 , and 24.39 ±3.08 ,which were sig-nificantly higher than control group (22.46 ±6.22,10.36 ±4.22) and non-depressed CHD patients (29.36 ±5.34, and 10.30 ± 4.11 ) ( P 0.05 ) .CRP and LDL levels of patients with CHD +depression were ( 24.36 ±3.25 ) mg/L, ( 2.85 ± 1.42 ) mmol/L, which were significantly higher than control group and non-depressed CHD patients ( P <0.05 ) .CRP and LDL lev-els of non-depressed CHD patients were higher than control group ( P <0.05 ) .SDS, and HAMD scores had a positive correlation with CRP, LDL, and heart rate ( P <0.05).Conclusions CHD patients should remain optimistic relaxed state of mind to improve the treatment of coronary heart disease .

Expression and significance of Wnt1 and β-catenin proteins in breast invasive ductal carcinoma / 中国医师杂志

Objective To investigate the expressions of Wnt1 and β-catenin proteins in mammary cancer and its relationship with clinical pathological characteristics,and explore its role in the pathogenesis of breast cancer.Methods Immunoshistochemisty (SP method) was used to detect the expressions of Wnt1 and β-catenin proteins in adjacent tissue of breast cancer (n =15),breast hyperplasia tissues (n =25),and breast in vasive ductal carcinoma (n =80).SPSS 17.0 statistical software was used for analysis,such as count data with x2 test and correlation analysis with Spearman test,with significance level of α =0.05.Results The positive rate of Wnt1 and β-catenin in breast cancer group [62.5％ (50/80) and 68.8 (55/80)] was significantly higher than that in hyperplasia group [28％ (7/25) and 20％ (5/25)]and in borderline group [13.33 (2/15) and 13.33 (2/15)] with a significant difference (P ＜ 0.01).Positive expression of Wnt1 and abnormal expression of β-catenin in breast invasive ductal carcinoma were related to lymphatic metastasis (x2 =5.10,4.87,P ＜ 0.05).Abnormal expression of β-catenin was also related to the histological grading of breast invasive ductal carcinoma (x2 =5.61,P ＜ 0.05).The expressions of Wnt1 and β-catenin proteins in invasive ductal carcinoma showed a positive correlation (r =0.313,P ＜ 0.01).Conclusions The high level expression of Wnt1 protein and the abnormal expression of β-catenin protein might play an important role in breast carcinogenesis,and was related to lymph node metastasis.

Sarcopenia, exercise and muscle reconstruction / 中国组织工程研究

BACKGROUND:Sarcopenia is the muscle loss in the elderly with aging, and it is closely related to the degradation of muscle function in the elderly. The research on the mechanism of sarcopenia as wel as effect of movement intervention is developed. OBJECTIVE:To summary the mechanisms of sarcopenia cel level as wel as the effect of movement intervention. METHODS:A computer-based retrieval was conducted on CNKI database and PubMed database for literatures on sarcopenia and elderly resistance training from January 2000 to December 2012. The key words were “sarcopenia, muscle, resistance training, aging, protein metabolism”. The literatures on sarcopenia, protein metabolism and resistance training were included, and the obsolete and repetitive literatures and the literatures lack of credibility were excluded. Final y, 58 literatures were included for analysis. RESULTS AND CONCLUSION:Resistance training can inhibit sarcopenia to a certain extent, so that to increase muscle mass in the elderly and promote the recombinant of motor units. But the recombinant is limited to the mutual conversion between the type Ⅱa and Ⅱb fibers. Resistance training combined with protein supplement can effectively promote elderly muscle reconstruction;the elderly muscle anabolic response confrontation reaction after resistance training is slower than young people, but the inflammatory response after training is stronger than younger people. However, Omega-3 has a good effect on the elimination of such inflammatory response.

Resistance training and protein supplement：Improvement of elderly muscle protein metabolism / 中国组织工程研究

10.3969/j.issn.2095-4344.2013.24.025

Protein turnover, amino acid requirements and recommendations for athletes and active populations

Skeletal muscle is the major deposit of protein molecules. As for any cell or tissue, total muscle protein reflects a dynamic turnover between net protein synthesis and degradation. Noninvasive and invasive techniques have been applied to determine amino acid catabolism and muscle protein building at rest, during exercise and during the recovery period after a single experiment or training sessions. Stable isotopic tracers (13C-lysine, 15N-glycine, ²H5-phenylalanine) and arteriovenous differences have been used in studies of skeletal muscle and collagen tissues under resting and exercise conditions. There are different fractional synthesis rates in skeletal muscle and tendon tissues, but there is no major difference between collagen and myofibrillar protein synthesis. Strenuous exercise provokes increased proteolysis and decreased protein synthesis, the opposite occurring during the recovery period. Individuals who exercise respond differently when resistance and endurance types of contractions are compared. Endurance exercise induces a greater oxidative capacity (enzymes) compared to resistance exercise, which induces fiber hypertrophy (myofibrils). Nitrogen balance (difference between protein intake and protein degradation) for athletes is usually balanced when the intake of protein reaches 1.2 g·kg-1·day-1 compared to 0.8 g·kg-1·day-1 in resting individuals. Muscular activities promote a cascade of signals leading to the stimulation of eukaryotic initiation of myofibrillar protein synthesis. As suggested in several publications, a bolus of 15-20 g protein (from skimmed milk or whey proteins) and carbohydrate (± 30 g maltodextrine) drinks is needed immediately after stopping exercise to stimulate muscle protein and tendon collagen turnover within 1 h.

Effect of goal of blood glucose control on protein metabolism in the patients with critically cerebral disease / 肠外与肠内营养

Objective: To investigate the effect of three different goals of blood glucose control by insulin therapy on protein metabolism in the patients with critically cerebral disease.Methods: We performed a prospective,randomized,controlled study.A total of 122 patients with critically cerebral disease were randomly divided into three groups according to the target glucose-control levels:Group A: 4.4-6.1 mmol/L(n=41),Group B: 6.1-8.3 mmol/L(n=42),and Group C: 10-11.1 mmol/L(n=39).The state of protein metabolism and ratio of hypoglycemia of three groups were compared.Results: The indicators of nitrogen balance,prealbumin and transferrin in group A and group B were significantly better than that in group C(P<0.05),but the ratio of hypoglycemia in group A was significantly higher than those in group B and group C(P<0.05).Conclusion: Maintaining the blood glucose level ≤8.3 mmol/L might improve the nutrition status in the patients with critically cerebral disease by decreasing catabolism and promoting synthesis of protein.

Alteration in protein metabolic profiles in gastrocnemius muscle tissue of rats during cypermethrin toxicosis.

Cypermethrin is the most widely used Type II pyrethroid pesticide in India because of its high efficacy against target species, and its reportedly low mammalian toxicity. It is a fast-acting neurotoxin and is known to cause free radical-mediated tissue damage. This paper is an attempt at estimating its toxicity in rats at a molecular level. Following exposure to oral, sublethal doses (41 mg/kg bw) of cypermethrin as single dose, double dose, and multiple dose with 48 h interval, the various profiles of protein metabolism were studied in different groups of rat muscle tissue. Total proteins showed decrement, whereas free amino acids, and the activity of protease, aspartate aminotransferase, alanine aminotransferase and glutamate dehydrogenase as well as ammonia significantly increased in cypermethrin-exposed rats. Urea content increase at all doses of exposure was not statistically significant. These effects on the protein metabolism of rats exposed to cypermethrin, which cause impairment of protein synthetic machinery, indicate its toxic effects on cellular functioning.

Capacidade da Lipoproteína de Alta Densidade (HDL) de receber lipídeos em diferentes faixas etárias: um estudo in vitro utilizando uma lipoproteína artificial / Capacity of the High Density Lipoprotein (HDL) to receive lipids in different age: a study in vitro using an artificial nanoemulsion

A relação entre transferência de lipídeos, idade e aterogênese são complexas e ainda não estão claras. É possível que a troca de lipídeos esteja alterada com a avançar da idade e relacionada com a Doença Arterial Coronariana (DAC). O objetivo deste trabalho foi verificar a hipótese se em indivíduos mais jovens a habilidade da HDL de receber lipídeos é diferente de indivíduos mais velhos com e sem a evidência clínica da DAC. Dentro desses aspectos, foram determinados o diâmetro da partícula desta lipoproteína, a atividade da Paraoxonase (PON1) e sua capacidade de receber lipídeos. Para tanto, foram estudados 86 indivíduos divididos em quatro grupos: adulto jovem (25±4), meia-idade (42±8), idosos sem evidência clínica de DAC (75±6) e idosos com DAC (74±5). Uma nanoemulsão artificial rica em colesterol (LDE) marcada com 3H-TG e 14C-CL ou 3H-CE e 14C-FL foi incubada com plasma. Após a precipitação de outras lipoproteínas, o sobrenadante contendo HDL foi separado e em seguida, medida a radioatividade. O diâmetro da HDL foi medido por laser scattering (nm). Foram constatadas diferenças significativas entre as taxas de transferência de 3H-éster de colesterol (CE) entre os grupos: adulto jovem (3.7±1.0%); meia idade (4.1 ±0.7%) e idosos (5.3±1.8%);p= 0.024. Também ocorreu diferença entre as taxas de transferência do 14C-fosfolipídeo (FL): adulto jovem (18.7±4.6%), meia idade (18.3 ±4.0%) e idosos (20.6±5.3); p=0.0368. Com relação ao tamanho das partículas de HDL, foi encontrada diferença entre os grupos: os grupos adulto jovem (8.9± 0.3nm) e meia idade (8.9± 0.3nm) apresentaram menores diâmetros de HDL quando comparados ao do grupo de idosos sem evidência clínica da DAC (9.7± 1.6);p= 0,0444. As transferências de lipídeos foram expressas em % de radioatividade. A idade correlacionou-se positivamente com a taxa de transferência do 3H- éster de colesterol (r=0.3365; p=0.0036), com a concentração de colesterol total (r=0.4965; p=0.0001) e com a concentração de HDL colesterol (r=0.3559; p=0.0023). Também houve correlação positiva com o tamanho de HDL (r=0.3695; p=0.0013). Em princípio, os indivíduos idosos sem evidência clínica da DAC, aparentemente têm alguma proteção contra a mesma. Desse modo, com o intuito de saber se os resultados encontrados no presente trabalho sustentam a afirmação acima, foi realizada a comparação desse grupo com um grupo de idosos que apresentavam a DAC. O grupo com DAC apresentou menor tamanho de partícula de HDL (8,7±0,7). As taxas de transferência de 3H-CE e de 14C-FL também foram menores neste grupo (3H-CE=3,1 ±2,3 e 3H-TG= 5,1 ±1 ,6). Devido ao importante papel antiaterogênico da HDL, esses resultados podem ser relevantes para estabelecer novos mecanismos existentes entre os aspectos qualitativos dessa lipoproteína, o avanço da idade e a presença da DAC

The relationship between transfer of lipids, age and atherogenesis are complex and yet unclear and is possible that the shift of lipids to HDL may be altered by the aging process and related with coronary artery disease (CAD). We tested the hypothesis whether in younger patients the ability of HDL to receive lipids is different from that of elderly patients with or without CAD. Inside of these aspects, the HDL size, the activity of Paraoxonase (PON1) and its capacity to receive lipids was determined. It was studied, 25 younger, 25 middle age, 36 elderly patients with a coronariography and/or a perfusion scintilography on the last 6 months (11 with CAD, 74±5 yo; and 25 patients without proved CAD, 75±6 yo). An artificial cholesterol-rich nanoemulsion labeled with 3H-TG and 14C-FC or H-CE and 14C-PL was incubated, per 1 hour, with plasma. After chemical precipitation of apoB-containing lipoproteins and the nanoemulsion, the supernatant containing HDL was counted for radioactivity. The HDL diameter was measured by laser-light-scattering. Transfer of CE and PL to HDL was smaller in young patients than in the elderly patients without CAD, but the transfer of the other lipids are equal (CE: young= 3.7±1.0%; middle age= 4.1 ±0.7%; elderly without CAD= 5.3±1.8%; p= 0.024 and PL: young= 18.7±4.6%; middle age= 18.3 ±4.0%; elderly without CAD= 20.6±5.3; p=0.0368). The HDL size was greater in elderly group without CAD (9.7± 1.6nm) than in younger (8.9± 0.3nm) and middle age patients (8.9± 0.3nm); p=0,0444. Transfer of lipids to HDL was expressed as % of total incubated radioactivity. The age positively correlated with the transfer of CE (r=0.3365; p=0.0036), with the total cholesterol concentration (r=0.4965; p=0.0001) and with the HDL concentration cholesterol (r=0.3559; p=0.0023). Also had positive correlation with the size of HDL (; p=0.0013). In principle, the aged patients without CAD, have some protection against the same one. In this aspect, with intention to know if the results found in the present work support the affirmation above, was compared this group with a group of aged that presented the CAD. Comparing elderly patients without CAD with elderly patients with CAD, the transfer of CE and FL as well as HDL size was smaller in the CAD group (CE=3.1±2.3 and TG= 5.1±1.6; 8.7±0.7nm). Due to HDL important antiatherogenic roles, this result can be relevant to establish new mechanisms and risk factors in aging and in CAD

Influence of Protein Jelly Supplementation on Protein Metabolish and Wound Healing in Post-Operated Children / 实用儿科临床杂志

0.05).And the increasing of weight in high protein+plus prolein jelly group was significantly higher than those of other two groups(Pa

Effects of Laparoscopic and Open Appendectomy on Humoral Immunity and Protein Metabolism in Children / 中国微创外科杂志

0.05).Compared to OA group,the patients in the LA group had shorters periods of absolute diet and hospital stay(P=0.000,P=0.000).Conclusions LA has less influence on the humoral immunity and protein metabolism in children.Meanwhile the procedure is minimally invasive,patients recover quickly and are discharged earlier after the operation.

Metabolismo protéico em peixes / Protein metabolism in fish

O conhecimento sobre o metabolismo protéico em peixes é de grande utilidade para a aqüicultura, tendo em vista que todas as espécies apresentam elevados índices de exigências nutricionais destes nutrientes (proteínas e aminoácidos). Além do mais, a dieta é a principal fonte protéica para peixes cultivados, e os alimentos protéicos são os ingredientes de maior custo na composição destas rações. Contudo em geral, o metabolismo protéico dos animais não – ruminantes e dos peixes é semelhante, quanto à ingestão, digestão e absorção, e direcionamento dos aminoácidos absorvidos à síntese de novas proteínas, compostos não – protéicos ou, então, desviados para vias de degradação para a produção de energia. Apesar das semelhanças, particularidades dos peixes como reduzida capacidade de utilização de carboidratos, faz destes animais eficientes utilizadores de proteínas como fonte de energia. Por fim, com relação a excreção dos resíduos nitrogenados, os peixes de água doce liberam principalmente a amônia e pequenas quantidades de uréia; enquanto peixes de água salgada excretam basicamente uréia.

Change of GH/IGF axis and the correlation between GH/IGF axis and protein metabolism in old people with pulmonary infection / 中国实用内科杂志

Objective To investigate the change of GH-IGF ax is and the correlation between GH-IGF axis and protein metabolism in old people w ith pulmonary infection.Methods Serum GH,IGF-Ⅰ,IGFBP-1,IGFBP-3,total protein,albumi n,prealbumin and transferrin levels were detected in 20 aged patients with pulmo nary infection and 12 controls.The patients were admitted to the department of g eriatrics and emergency from Jul 2002 to Jan 2003.Results (1)The level of serum IGF-Ⅰin old people with pulmona ry infection was significantly lower than the control(P

Aspectos do metabolismo energético e protéico em idosos / Aspects of energy and protein metabolism in the elderly

The nutritional condition of elderly persons has close relations with their immunologic status and general health. There is no agreement regarding the recommended dietary allowances of energy and of the various nutrients inthe elderly population. Also, studies on this field were carried out in developed Countries, with possibly different cultural, social, and even climatic conditions if compared with Brazil. This paper revises some aspects of the energy and protein metabolism in elderly persons and highlights the necessity for new research lines about the nutritional status and the adequacy of the caloric and protein intake of our aged population in order to enable the development of rational nutritional interventions

El estado nutricional de lo adultos mayores influye en su sistema inmunológico y la salud. No existe un consenso acerca de las necesidades calóricas y de nutrientes para esta población. La mayor parte de los estudios de estas variables fueron realizados en países desarrollados, con condiciones culturales, sociales y hasta climáticas, bastante diferentes del Brasil. Se revisaron algunos aspectos del metabolismo enegético y proteico de los adultos mayores, señalando los estudios necesários para uma evaluación del estado nutricional, que permitan el ajuste correcto de estos parámetros en la dieta de los adultos mayores, elementos indispensables para la planificación de intervenciones nutricionales racionales

O estado nutricional dos idosos é relacionado com o seu estado imunológico e saúde geral. Não existe consenso sobre as necessidades calóricas e dos diversos nutrientes na população idosa. Também, a maioria dos estudos acerca destas variáveis foram realizados em países desenvolvidos, com cultura, condições sociais e mesmo climáticas diferentes daquelas do Brasil. O presente artigo revisa alguns aspectos do metabolismo energético e protéico em idosos, destacando a necessidade da realização de pesquisas para a avaliação do estado nutricional e da adequação calórica e protéica da dieta habitual da nossa população idosa, essenciais para o planejamento de intervenções nutricionais racionais